Sequence information
Variant position: 543 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 590 The length of the canonical sequence.
Location on the sequence:
GLAGGSSGSYYSSSSGGVGL
G GGLSVGGSGFSASSGRGLGV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLAGGSSG------------SYYSSSSGGVGLG GGLSVGGSGFSASSGRGLGV
Chimpanzee SLAGGGSG------------SYYSSSSGGVGLG GGLSVGGS
Mouse GL-----G------------PRFTRGGGGLGLG SGLSVGGS
Rat DI-----G------------PLLNRR----GLG SGLSVGGS
Bovine GLGGGLGGGLGSGLGGGGSSSFYSSSSGGVGLG GGLSVGGS
Xenopus laevis --------------------------------- --------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 590
Keratin, type II cytoskeletal 5
Region
478 – 590
Tail
Compositional bias
528 – 590
Ser-rich
Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLY-528 AND SER-543;
Isolation and characterization of a cDNA clone coding for human epidermal keratin K5. Sequence of the carboxyterminal half of this keratin.
Galup C.; Darmon M.Y.;
J. Invest. Dermatol. 91:39-42(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 348-590; VARIANT SER-543;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.