Variant position: 475 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 594 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AALALASSENSSSTPEECEE MSEKPKKKKKQKPQEVPQENG
Mouse AALALASSENSST-PEECEE VNEKSKKKKKLKPQ----ENG
Bovine AAIALASSENSSA-PEECEE TSERPKKKKKQKPQEVLQENG
Caenorhabditis elegans ------LAEESVTATAEAEV DEDAPKPKKKKKSK-------
Slime mold ------ESEPTEEKSSKKSK KEEKSSKKSKSDDVEMKEEPV
Baker's yeast ------LEDDDEEKKEKKEK KSKKEKKEKKEKKD-------
Fission yeast ------TVETISEKPSKKEK KDKKEKKKEKSKKKR------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 594 Nucleolar protein 56
438 – 589 Lys-rich
466 – 466 Phosphoserine
467 – 467 Phosphoserine
468 – 468 Phosphothreonine
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis.
Gautier T.; Berges T.; Tollervey D.; Hurt E.;
Mol. Cell. Biol. 17:7088-7098(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; SUBCELLULAR LOCATION; VARIANT THR-475;
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