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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q68CQ4: Variant p.Gln67Glu

U3 small nucleolar RNA-associated protein 25 homolog
Gene: UTP25
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Variant information Variant position: help 67 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glutamine (Q) to Glutamate (E) at position 67 (Q67E, p.Gln67Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (Q) to medium size and acidic (E) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help Decreases degradation of p53/TP53. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 67 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 756 The length of the canonical sequence.
Location on the sequence: help CQLSESSDSSDSESDSESEP Q QVSGYHRLLATLKNVSEEEE The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         CQLSESS-DSSDSESDSESEPQQVSG-YHRLLATLKNVS-------EEEE

Mouse                         CQLPESS-DSSHSESESESEQEHVSG-YHRLLATLKNVSEE

Rat                           CQLSESS-DSSHSESESESEQEHVSG-YHRLLATLKNISEE

Chicken                       CELSDNS-DKSSAESDSETEVEQVSV-YHKLLATLKASP--

Xenopus tropicalis            VQLPESSEDESRSESEAESDPEPVNM-YHKLLATLNTVS--

Zebrafish                     LRLPDSP-QRPEPDSEDDSDAEQPSA-YQKLLSTMIQGDED

Baker's yeast                 --------KRSSARTEGGSTE------------TLEDVA--

Fission yeast                 --------MAIESDLDGASMDELAGKSYEALLYLMNKNK--

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 756 U3 small nucleolar RNA-associated protein 25 homolog
Region 1 – 185 Promotes p53/TP53 degradation
Region 1 – 159 Disordered
Modified residue 50 – 50 Phosphoserine
Modified residue 52 – 52 Phosphoserine
Modified residue 58 – 58 Phosphoserine
Modified residue 60 – 60 Phosphoserine
Modified residue 62 – 62 Phosphoserine
Modified residue 64 – 64 Phosphoserine



Literature citations
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLU-67 AND ASP-111; Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Tao T.; Shi H.; Guan Y.; Huang D.; Chen Y.; Lane D.P.; Chen J.; Peng J.;
Cell Res. 23:620-634(2013)
Cited for: VARIANTS GLU-67 AND ASP-111; CHARACTERIZATION OF VARIANTS GLU-67 AND ASP-111; FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH CAPN3;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.