Variant position: 67 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 756 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CQLSESS-DSSDSESDS-------ESEP QQVSGYHRLLATLKNVS-------------EEEE
Mouse CQLPESS-DSSHSESES-------ESEQ EHVSGYHRLLATL
Rat CQLSESS-DSSHSESES-------ESEQ EHVSGYHRLLATL
Chicken CELSDNS-DKSSAESDS-------ETEV EQVSVYHKLLATL
Xenopus tropicalis VQLPESSEDESRSESEA-------ESDP EPVNMYHKLLATL
Zebrafish LRLPDSP-QRPEPDSED-------DSDA EQPSAYQKLLSTM
Baker's yeast EDIDHRSDEDEVSDVDSGDDFDIEDEEG KKEKVYDALLTIL
Fission yeast YLMNKNKKRKPEKKDDK-------EKSS KKVQKKNKVIESL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 756 U3 small nucleolar RNA-associated protein 25 homolog
1 – 185 Promotes p53/TP53 degradation
1 – 159 Disordered
50 – 50 Phosphoserine
52 – 52 Phosphoserine
58 – 58 Phosphoserine
60 – 60 Phosphoserine
62 – 62 Phosphoserine
64 – 64 Phosphoserine
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLU-67 AND ASP-111;
Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.
Tao T.; Shi H.; Guan Y.; Huang D.; Chen Y.; Lane D.P.; Chen J.; Peng J.;
Cell Res. 23:620-634(2013)
Cited for: VARIANTS GLU-67 AND ASP-111; CHARACTERIZATION OF VARIANTS GLU-67 AND ASP-111; FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH CAPN3;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.