Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 390 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PLAPRRRRYTLTPARLRWDH FNLTYRILSFPRNLLSPRETR
Mouse MSVTRRRRYTLTPARLRWDH FNLTYRVLSFPRNLLSPEETR
Rat MLVTRRRRYTLTPARLRWDH FNLTYRILSFPRNLLSPEETR
Bovine PPVPRRRRYTLTPARLRWEH FNLTYKILSFPRNLLSPSETR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 390 Matrix metalloproteinase-23
79 – 390 Matrix metalloproteinase-23, soluble form
41 – 390 Lumenal
92 – 92 N-linked (GlcNAc...) asparagine
78 – 78 R -> G. Abolishes processing of soluble form.
Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3.
Gururajan R.; Grenet J.; Lahti J.M.; Kidd V.J.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3); VARIANT LEU-91;
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