Sequence information
Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 390 The length of the canonical sequence.
Location on the sequence:
PLAPRRRRYTLTPARLRWDH
F NLTYRILSFPRNLLSPRETR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PLAPRRRRYTLTPARLRWDHF NLTYRILSFPRNLLSPRETR
Mouse MSVTRRRRYTLTPARLRWDHF NLTYRVLSFPRNLLSPEETR
Rat MLVTRRRRYTLTPARLRWDHF NLTYRILSFPRNLLSPEETR
Bovine PPVPRRRRYTLTPARLRWEHF NLTYKILSFPRNLLSPSETR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 390
Matrix metalloproteinase-23
Chain
79 – 390
Matrix metalloproteinase-23, soluble form
Topological domain
41 – 390
Lumenal
Glycosylation
92 – 92
N-linked (GlcNAc...) asparagine
Mutagenesis
78 – 78
R -> G. Abolishes processing of soluble form.
Literature citations
Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3.
Gururajan R.; Grenet J.; Lahti J.M.; Kidd V.J.;
Genomics 52:101-106(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3); VARIANT LEU-91;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.