Variant position: 471 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 824 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ELPVPGLSQAATMPAPLPSP SSCDLTQQL----LPQTVLQSTPAP
Mouse ELPVQGLSQAATMPTALHSS ASCDLTKQLLLQSLPQTGLQS
Chicken DLSAHRLSQPTALQASLPSQ PSCELLPQQL---LPQATLQS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 824 Neuronal PAS domain-containing protein 2
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.
Zhou Y.-D.; Barnard M.; Tian H.; Li X.; Ring H.Z.; Francke U.; Shelton J.; Richardson J.; Russell D.W.; McKnight S.L.;
Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ALA-394 AND LEU-471;
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference.
Johansson C.; Willeit M.; Smedh C.; Ekholm J.; Paunio T.; Kieseppa T.; Lichtermann D.; Praschak-Rieder N.; Neumeister A.; Nilsson L.G.; Kasper S.; Peltonen L.; Adolfsson R.; Schalling M.; Partonen T.;
Cited for: ASSOCIATION OF VARIANT LEU-471 WITH SAD;
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