UniProtKB/Swiss-Prot P34972: Variant p.His316Tyr

Cannabinoid receptor 2
Gene: CNR2
Chromosomal location: 1p36.11
Variant information

Variant position:  316
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Histidine (H) to Tyrosine (Y) at position 316 (H316Y, p.His316Tyr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (H) to large size and aromatic (Y)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.

Sequence information

Variant position:  316
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  360
The length of the canonical sequence.

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

Chain 1 – 360 Cannabinoid receptor 2
Topological domain 302 – 360 Cytoplasmic
Modified residue 335 – 335 Phosphoserine
Modified residue 336 – 336 Phosphoserine

Literature citations

Amplification and cloning of human cannabinoid receptor 2 gene from Asiatic origin.
Saravanan T.; Chugh A.; Kant R.;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.
Onaivi E.S.; Ishiguro H.; Gong J.-P.; Patel S.; Meozzi P.A.; Myers L.; Perchuk A.; Mora Z.; Tagliaferro P.A.; Gardner E.; Brusco A.; Akinshola B.E.; Hope B.; Lujilde J.; Inada T.; Iwasaki S.; Macharia D.; Teasenfitz L.; Arinami T.; Uhl G.R.;
PLoS ONE 3:E1640-E1640(2008)
Cited for: VARIANTS ARG-63 AND TYR-316;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.