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UniProtKB/Swiss-Prot Q92820: Variant p.Thr151Ile

Gamma-glutamyl hydrolase
Gene: GGH
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Variant information Variant position: help 151
Type of variant: help LB/B
Residue change: help From Threonine (T) to Isoleucine (I) at position 151 (T151I, p.Thr151Ile).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (I)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 151
Protein sequence length: help 318
Location on the sequence: help WGTCLGFEELSLLISGECLL T ATDTVDVAMPLNFTGGQLHS
Residue conservation: help 
Human                         WGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHS

Mouse                         WGTCLGFEELSVLVSGENLLTSTDTKSKKLPLNFTEGARKS

Rat                           WGTCLGLEELSVLVSNDNLLTLTNTSSVKLPLNFTRDSKQS

Bovine                        WGTCLGFEELIYLVSGESLLTLTDTVGIKLPLNFSRGTLQS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 25 – 318 Gamma-glutamyl hydrolase
Domain 25 – 318 Gamma-glutamyl hydrolase
Active site 134 – 134 Nucleophile
Glycosylation 163 – 163 N-linked (GlcNAc...) asparagine
Mutagenesis 134 – 134 C -> A. Loss of activity.
Beta strand 151 – 160



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.