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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P42684: Variant p.Lys930Arg

Tyrosine-protein kinase ABL2
Gene: ABL2
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Variant information Variant position: help 930
Type of variant: help LB/B
Residue change: help From Lysine (K) to Arginine (R) at position 930 (K930R, p.Lys930Arg).
Physico-chemical properties: help Similar physico-chemical property. Both residues are large size and basic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 930
Protein sequence length: help 1182
Location on the sequence: help QPGWPSPAKAAPVLPTTHNH K VPVLISPTLKHTPADVQLIG
Residue conservation: help 
Human                         QPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIG

Mouse                         QLGWSSPAKAVAVLPTTHNHKVPVLISPTLKHTPADVQLIG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 1182 Tyrosine-protein kinase ABL2
Region 694 – 930 F-actin-binding
Modified residue 915 – 915 Phosphoserine
Modified residue 936 – 936 Phosphoserine
Alternative sequence 565 – 1182 Missing. In isoform 8.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-930; MET-946; ARG-996; ASN-1085 AND ALA-1101; Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-78; GLN-99; ILE-519; SER-769; ARG-930 AND ARG-996; VARIANT [LARGE SCALE ANALYSIS] THR-12 (ISOFORM 4);
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.