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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P52701: Variant p.Pro623Ala

DNA mismatch repair protein Msh6
Gene: MSH6
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Variant information Variant position: help 623
Type of variant: help LB/B
Residue change: help From Proline (P) to Alanine (A) at position 623 (P623A, p.Pro623Ala).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and hydrophobic (A)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 623
Protein sequence length: help 1360
Location on the sequence: help KETKTILKSSLSCSLQEGLI P GSQFWDASKTLRTLLEEEYF
Residue conservation: help 
Human                         KETKTILKSSLSCSLQEGLI-PGSQFWDASKTLRTLLEEEYF

Mouse                         TETKTVLKGSLSSCLQEGLI-PGSQFWDATKTLRTLLEGGY

Chicken                       VDTQKILKGSLISCIQEGLI-SGSQFWSASKTLKVLLEEEY

Drosophila                    QRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLK-LLAERY

Slime mold                    PKTISIMKRVLSTVKPVMNARLSLEYWDPTDTMERITQ---

Baker's yeast                 TLANKIVKFNSAPNAIFNEVKAGEEFYDCDKTYAEIISSEY

Fission yeast                 QKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1360 DNA mismatch repair protein Msh6



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLU-39; VAL-396; ALA-623 AND VAL-886;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.