Sequence information
Variant position: 258 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 351 The length of the canonical sequence.
Location on the sequence:
TRGSPNRSLPSPGVLCGSAR
P KPYDPPGEKMVAAKVKGEKL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human T-RGSPNRSLPSPGVLCGSARP KPY---DPPGEKMVAAKVKGE----KL
Mouse TSRAPPD-NLPSPGGSRGSPRP KPY---DPPGVS-LTAKVK
Rat TSRAPPD-SLPSPGVPRGS-RP KPY---DPPGVS-VTAKVK
Bovine TSRGSPNKSLLSPGALSGSSRP KPY---DPPGEKMVAAKVK
Zebrafish ---------------LEPSSRA KPYSRPDPEASPALKGRVK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 351
Cyclic AMP-dependent transcription factor ATF-4
Region
210 – 268
Disordered
Modified residue
245 – 245
Phosphoserine; by RPS6KA3
Modified residue
248 – 248
Phosphoserine
Cross
259 – 259
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross
267 – 267
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross
272 – 272
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Mutagenesis
245 – 245
S -> A. Abolished phosphorylation by RPS6KA3/RSK2.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.