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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04114: Variant p.Pro877Leu

Apolipoprotein B-100
Gene: APOB
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Variant information Variant position: help 877
Type of variant: help LB/B
Residue change: help From Proline (P) to Leucine (L) at position 877 (P877L, p.Pro877Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Polymorphism: help Genetic variations in APOB define the low density lipoprotein cholesterol level quantitative trait locus 4 (LDLCQ4) [MIM:615558].
Other resources: help


Sequence information Variant position: help 877
Protein sequence length: help 4563
Location on the sequence: help GAKAGVKLEVANMQAELVAK P SVSVEFVTNMGIIIPDFARS
Residue conservation: help 
Human                         GAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARS

Mouse                         GIKAGVRLELANIQAELVAKPSVSLEFVTNMGIIIPDFAKS

Rat                           GIKAGVRLELANIQAELVAKPSVSLEFVTNMGIIIPDFAKS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 28 – 4563 Apolipoprotein B-100
Chain 28 – 2179 Apolipoprotein B-48



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.