Variant position: 154 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 206 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LYIAESTSGR-GQCLKRIRYH GRGRFGIMEKVYCHYFVKLV-----E
Mouse LHIAESTSGR-GQCLKRIRYH GRGRFGIMEKVYCHYFVKLV
Rat LHIAESTSGR-GQCLKRIRYH GRGRFGIMEKVYCHYFVKLV
Bovine LYIAESTSGR-GQYLKRIRYH GRGRFGIMEKVFCHYFVKLV
Xenopus tropicalis LYVAESFSNK-GKYLKRIRYH GRGMFGIMDKVYCHYFVKLV
Drosophila LWIAESFVGK-GRVFKGVRRH ARGRFGKVEYKHCHYFVRLE
Slime mold LIISQIWAGR-SFYKRSIMWK GRGQGSTIRKPFCHVSVEIK
Baker's yeast LYISQIWTGSDGFWRKRVEFK ARTRIGIISHPYIHVRCILR
Fission yeast LYVDQIWVGK-AKYLKKLITM GRGGRAIERSPRVRVTVVLR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
41 – 206 39S ribosomal protein L22, mitochondrial
154 – 156
No reference for the current variant in UniProtKB/Swiss-Prot.
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