Variant position: 1472 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2813 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EIVSYLCDLAPEAPPPTLPP DMAQVTVGPGLLGVSTLGPKR
Mouse EIVSYLCDLAPEAPAPTQPP QVAHVTVSPGIAGISSPGPKR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
764 – 2813 von Willebrand factor
1468 – 1468 O-linked (GalNAc...) threonine
1477 – 1477 O-linked (GalNAc...) threonine
1486 – 1486 O-linked (GalNAc...) serine
1487 – 1487 O-linked (GalNAc...) threonine
315 – 2813 Missing. In isoform 2.
Nucleotide sequence of pre-pro-von Willebrand factor cDNA.
Bonthron D.; Orr E.C.; Mitsock L.M.; Ginsburg D.; Handin R.I.; Orkin S.H.;
Nucleic Acids Res. 14:7125-7128(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS ARG-852; ALA-1381 AND HIS-1472;
Structure of the gene for human von Willebrand factor.
Mancuso D.J.; Tuley E.A.; Westfield L.A.; Worrall N.K.; Shelton-Inloes B.B.; Sorace J.M.; Alevy Y.G.; Sadler J.E.;
J. Biol. Chem. 264:19514-19527(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-471; ARG-852; ALA-1381 AND HIS-1472;
Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction.
Mancuso D.J.; Tuley E.A.; Westfield L.A.; Lester-Mancuso T.L.; Le Beau M.M.; Sorace J.M.; Sadler J.E.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 990-1947; VARIANTS ALA-1381 AND HIS-1472;
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