Variant position: 2 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 223 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human M QWAVGRRW-AWAALLLAVAAVL
Mouse M PWAAGRRW-AWITLILTIIAV
Rat M PWAVGRRW-AWITLFLTIVAV
Bovine M CWAVGRRW-AWAALLLAVAAV
Chicken - -MGVAGPWVLRVGLGLGAFAL
Xenopus laevis - -MALWLG--LRAVLVVAGLAV
Xenopus tropicalis - -MALWRG--LRAVLAVAGLAV
Zebrafish - -MSLIRTI-LKLVVVVGFLSL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 223 Sigma non-opioid intracellular receptor 1
1 – 9 Lumenal
2 – 8 Targeting to endoplasmic reticulum-associated lipid droplets
1 – 3
Lack of association between sigma receptor gene variants and schizophrenia.
Satoh F.; Miyatake R.; Furukawa A.; Suwaki H.;
Psychiatry Clin. Neurosci. 58:359-363(2004)
Cited for: VARIANTS PRO-2 AND GLN-211;
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