Variant position: 211 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 223 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FSTQDFLTLFYTLRSYARGL RLELTTYLFGQDP-
Mouse FSTQDYLTLFYTLRAYARGL RLELTTYLFGQDS
Rat FSTQDFLTLFYTLRAYARGL RLELTTYLFGQDP
Bovine FSTQDFLTLFYTLRAYARGL RLELTTYLFGQDA
Chicken FSTQDFITLFYTLRAYTKGL LLEASAFFSTLGC
Xenopus laevis FSTQDFLTLFYTVKVYSKAL LLEASTHLSQLGF
Xenopus tropicalis FSTQDFLTLFYTVKVYGKAL LLETSTHLSELGF
Zebrafish FSTQDFLTLFYTARVYVKGM ILEASTFLTESGV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 223 Sigma non-opioid intracellular receptor 1
31 – 223 Cytoplasmic
177 – 223 C-terminal hydrophobic region
107 – 223 Missing. In isoform 4.
195 – 195 D -> G. No effect on ligand-binding.
213 – 213 E -> G. No effect on ligand-binding.
196 – 218
Lack of association between sigma receptor gene variants and schizophrenia.
Satoh F.; Miyatake R.; Furukawa A.; Suwaki H.;
Psychiatry Clin. Neurosci. 58:359-363(2004)
Cited for: VARIANTS PRO-2 AND GLN-211;
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