Variant position: 202 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 359 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKDCCFEISAPDKRIYQFTA ASPKDAEEWVQQLKFVLQDME
Mouse KKDCCFEICAPDKRIYQFTA ASPKDAEEWVQQLKFILQDLG
Rat KKDCCFEICAPDKRIYQFTA ASPKDAEEWVQQLKFILQDMG
Bovine KKDCCFEISAPDKRIYQFTA ASPKDAEEWVQQLNFVLQDMG
Xenopus tropicalis KKDCCFEIFAPDKRVYQFAA SSPKEAEEWV---NIIMNSRG
Zebrafish KRDCCFEVSAPDKRVYQFCA ASEKEAKEWVEHIDFLIKDLG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 359 Src kinase-associated phosphoprotein 2
116 – 219 PH
197 – 197 Phosphotyrosine
RA70 is a src kinase-associated protein expressed ubiquitously.
Kouroku Y.; Soyama A.; Fujita E.; Urase K.; Tsukahara T.; Momoi T.;
Biochem. Biophys. Res. Commun. 252:738-742(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; INDUCTION; POSSIBLE INTERACTION WITH FYN; HCK AND LYN; FUNCTION; VARIANT SER-202;
SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55.
Marie-Cardine A.; Verhagen A.M.; Eckerskorn C.; Schraven B.;
FEBS Lett. 435:55-60(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; PHOSPHORYLATION; INTERACTION WITH FYB1; VARIANT SER-202;
Src-associated adaptor protein with PH and SH3 domain.
Lee J.-S.; Suh K.S.; Burr J.G.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT SER-202;
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