Variant position: 259 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 419 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VIHRDVKPSNILLDERGQIK LCDFGISGRLVDSKAKTRSAG
Mouse VIHRDVKPSNILLDERGQIK LCDFGISGRLVDSKAKTRSAG
Rat VIHRDVKPSNILLDERGQIK LCDFGISGRLVDSKAKTRSAG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 419 Dual specificity mitogen-activated protein kinase kinase 7
120 – 380 Protein kinase
243 – 243 Proton acceptor
271 – 271 Phosphoserine; by MAP3K
275 – 275 Phosphothreonine; by MAP3K
257 – 259
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli.
Foltz I.N.; Gerl R.E.; Wieler J.S.; Luckach M.; Salmon R.A.; Schrader J.W.;
J. Biol. Chem. 273:9344-9351(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); FUNCTION; TISSUE SPECIFICITY; VARIANT PHE-259;
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