Sequence information
Variant position: 227 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 967 The length of the canonical sequence.
Location on the sequence:
PTGKAETEDEDEGTEGEDEG
A QWSPQDPALQGVGQPTGTGS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PTGKAETEDEDEGTEGEDEGA QWSPQDPALQGVGQPTGTGS
Mouse PTS-------DSRPESQNTRN QWPVRDPTPQDAGKPSGPGS
Rat PTS-------NSGRESQNTPD QWPLRNPTPQGAGKPTGPGS
Baker's yeast ----------DTTVIVDADGR VWQ------------RGGGC
Fission yeast ------------------NFS TWT------------SRVGI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Cloning, characterization and mapping on human chromosome 21 of the orthologue of murine Adamts-1.
Casas C.; Pritchard M.A.; Estivill X.; Arbones M.L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-227;
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.
Vazquez F.; Hastings G.; Ortega M.-A.; Lane T.F.; Oikemus S.; Lombardo M.; Iruela-Arispe M.L.;
J. Biol. Chem. 274:23349-23357(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-227; FUNCTION;
Differential gene expression by endothelial cells in distinct angiogenic states.
Glienke J.; Schmitt A.O.; Pilarsky C.; Hinzmann B.; Weiss B.; Rosenthal A.; Thierauch K.H.;
Eur. J. Biochem. 267:2820-2830(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-227;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.