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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8TCC7: Variant p.Val448Ile

Organic anion transporter 3
Gene: SLC22A8
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Variant information Variant position: help 448
Type of variant: help LB/B
Residue change: help From Valine (V) to Isoleucine (I) at position 448 (V448I, p.Val448Ile).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 3
Other resources: help


Sequence information Variant position: help 448
Protein sequence length: help 542
Location on the sequence: help CLFLYTSELYPTVIRQTGMG V SNLWTRVGSMVSPLVKITGE
Residue conservation: help 
Human                         CLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGE

Mouse                         CLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGE

Rat                           CLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGE

Pig                           CLFLYTSELYPTVIRQTGMGASNLWARVGSMTAPLVKITGE

Rabbit                        CLFLYTSELFPTVIRQTGMGISNVWARVGSMISPLVKITGE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 542 Organic anion transporter 3
Topological domain 433 – 471 Cytoplasmic
Alternative sequence 406 – 455 DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV -> GERLGLPQNPLEEAARLGARDFTAGSASKSLCYLEQVPALSGAQGLSSRK. In isoform 3.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.