Variant position: 756 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1820 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EELKKRENESDSLIQELETS NKKIITQNQRIKELINIIDQK
Mouse EELKNRE--SNSLVQALKTS SK-------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1820 Kinesin-like protein KIF20B
674 – 793
1 – 1308 Missing. In isoform 5.
Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.
Kamimoto T.; Zama T.; Aoki R.; Muro Y.; Hagiwara M.;
J. Biol. Chem. 276:37520-37528(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); FUNCTION; SUBUNIT; SUBCELLULAR LOCATION; INTERACTION WITH PIN1; PHOSPHORYLATION AT THR-1644; VARIANTS ILE-756; LEU-789 AND ARG-1177;
M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.
Abaza A.; Soleilhac J.-M.; Westendorf J.; Piel M.; Crevel I.; Roux A.; Pirollet F.;
J. Biol. Chem. 278:27844-27852(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-957 (ISOFORM 3); NUCLEOTIDE SEQUENCE [MRNA] OF 705-1820 (ISOFORM 1); FUNCTION; INTERACTION WITH MICROTUBULES; PHOSPHORYLATION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANTS ILE-756; LEU-789 AND ARG-1177;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.