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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9NX55: Variant p.Ser97Pro

Huntingtin-interacting protein K
Gene: HYPK
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Variant information Variant position: help 97
Type of variant: help LB/B
Residue change: help From Serine (S) to Proline (P) at position 97 (S97P, p.Ser97Pro).
Physico-chemical properties: help Change from small size and polar (S) to medium size and hydrophobic (P)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 97
Protein sequence length: help 121
Location on the sequence: help LAKVTIKKEDLELIMTEMEI S RAAAERSLREHMGNVVEALI
Residue conservation: help
Human                         LAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALI

Mouse                         LAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALI

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 121 Huntingtin-interacting protein K
Region 52 – 121 Required for association with the NAA10-NAA15 complex
Coiled coil 62 – 107
Alternative sequence 78 – 121 Missing. In isoform 3.
Mutagenesis 52 – 121 Missing. Abolishes interaction with NAA10 and NAA15.



Literature citations
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Zhang Q.-H.; Ye M.; Wu X.-Y.; Ren S.-X.; Zhao M.; Zhao C.-J.; Fu G.; Shen Y.; Fan H.-Y.; Lu G.; Zhong M.; Xu X.-R.; Han Z.-G.; Zhang J.-W.; Tao J.; Huang Q.-H.; Zhou J.; Hu G.-X.; Gu J.; Chen S.-J.; Chen Z.;
Genome Res. 10:1546-1560(2000)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT PRO-97;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.