UniProtKB/SwissProt variant VAR

Huntingtin-interacting protein K
Gene: HYPK
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Variant information Variant position:

97
Type of variant:

LB/B
Residue change:

From Serine (S) to Proline (P) at position 97 (S97P, p.Ser97Pro).
Physico-chemical properties:

Change from small size and polar (S) to medium size and hydrophobic (P)
BLOSUM score:

-1
Other resources:

Variant rs12702 [ dbSNP | Ensembl ]

Sequence information Variant position:

97
Protein sequence length:

121
Location on the sequence:

LAKVTIKKEDLELIMTEMEI S RAAAERSLREHMGNVVEALI
Residue conservation:

Human                         LAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALI

Mouse                         LAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALI

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 121	Huntingtin-interacting protein K
Region	52 – 121	Required for association with the NAA10-NAA15 complex
Coiled coil	62 – 107
Alternative sequence	78 – 121	Missing. In isoform 3.
Mutagenesis	52 – 121	Missing. Abolishes interaction with NAA10 and NAA15.

Literature citations
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Zhang Q.-H.; Ye M.; Wu X.-Y.; Ren S.-X.; Zhao M.; Zhao C.-J.; Fu G.; Shen Y.; Fan H.-Y.; Lu G.; Zhong M.; Xu X.-R.; Han Z.-G.; Zhang J.-W.; Tao J.; Huang Q.-H.; Zhou J.; Hu G.-X.; Gu J.; Chen S.-J.; Chen Z.;
Genome Res. 10:1546-1560(2000)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT PRO-97;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9NX55: Variant p.Ser97Pro