Variant position: 528 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 655 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VMMFTLMMVAYSASSMALAI AAGQSVVSVATLLMTICFVFM
Rhesus macaque IMMFTLMMVAYSASSMALAI AAGQSVVSVATLLMTICFVFM
Mouse IMMFTLIMVAYTASSMALAI ATGQSVVSVATLLMTIAFVFM
Rat IMMFTLIMVAYTASSMALAI AAGQSVVSVATLLMTISFVFM
Pig IMMFTLMMVAYSASSMALAI AAGQSVVSVATLLMTISFVFM
Bovine IMMLTLMMVAYSASSMALAI AAGQSVVSIATLLMTISFVFM
Slime mold YFLLMNFVGDLAFQSFFKMV SAFAPNATLASVIAPAALAPF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 655 Broad substrate specificity ATP-binding cassette transporter ABCG2
528 – 535 Cytoplasmic
389 – 651 ABC transmembrane type-2
546 – 546 V -> A. No effect on stability. No effect on estrone-3 sulfate ATPase-coupled transmembrane transporter activity. No effect on substrate-induced ATP hydrolysis. No effect on substrate transport.
546 – 546 V -> F. No effect on stability. Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Increased basal and substrate-induced ATP hydrolysis. Decreased substrate transport.
504 – 528
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS MET-12; LYS-141; HIS-296 AND THR-528;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.