Variant position: 174 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1039 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EKTPVGSCFLAQPESGRRAE YSPCRGNTLSRIYVENDFSWD
Mouse EKTPVGGCFLAQLQSGGRAE YSPCRANTMSSVYAES-FRGD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects.
Kiyoi T.; Tomiyama Y.; Honda S.; Tadokoro S.; Arai M.; Kashiwagi H.; Kosugi S.; Kato H.; Kurata Y.; Matsuzawa Y.;
Cited for: VARIANT GT HIS-174; CHARACTERIZATION OF VARIANT GT HIS-174;
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