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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P08922: Variant p.Asp1776His

Proto-oncogene tyrosine-protein kinase ROS
Gene: ROS1
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Variant information Variant position: help 1776
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Histidine (H) at position 1776 (D1776H, p.Asp1776His).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (H)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 1776
Protein sequence length: help 2347
Location on the sequence: help PGIPKLLEGSKNSIQWEKAE D NGCRITYYILEIRKSTSNNL
Residue conservation: help 
Human                         PGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNL

Mouse                         PGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDS

Rat                           PGIPKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSISNDS

Chicken                       PGTPKRAEDSKNSVQWEKAEDNGSNLTYYILESRKQSGNTN
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 28 – 2347 Proto-oncogene tyrosine-protein kinase ROS
Topological domain 28 – 1859 Extracellular
Domain 1752 – 1854 Fibronectin type-III 9



Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-13; VAL-126; PRO-145; GLN-167; SER-224; CYS-338; PRO-370; HIS-419; MET-537; PHE-653; HIS-865; LEU-1109; PHE-1239; SER-1353; ARG-1370; GLY-1506; HIS-1776; LYS-1902; ASN-1999; ARG-2003; SER-2138; ASN-2203; GLU-2213; ASN-2213; GLN-2228; CYS-2229 AND LYS-2240;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.