Variant position: 23 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 299 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DKKLVVVFGGTGAQGGSVAR TLLEDGTFKVRVVTRNPRKKA
Mouse DRKLVVVFGATGAQGGSVAR ALLEDGTFRIRVVTRNPEQRA
Bovine DKKLVVVFGATGAQGGSVAR TLLEDGTFRVRVVTRDPGQRA
Chicken SKKLIVVFGATGAQGGSVAR ALLEDGAFAVRAVTRSPGRKE
Slime mold MSKKVLVFGGTGYQGGSVVR ELLKDDSFKVITLSRNPESEK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 299 NmrA-like family domain-containing protein 1
37 – 37 R -> A. Impairs binding to NADPH; abolishes the ability to dimerize; enhances binding to ASS1; reduces perinuclear localization.
41 – 41 K -> S. Does not impair binding to NADPH; maintains the dimerization properties as the wild type; does not affect binding to ASS1; does not affect perinuclear localization.
15 – 27
No reference for the current variant in UniProtKB/Swiss-Prot.
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