Sequence information
Variant position: 541 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 875 The length of the canonical sequence.
Location on the sequence:
ELMDLPTCGARNLKQHLAKA
T ASGIMGSPKPAIKSISASAL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ELMDLPTCGARNLKQHLAKAT ASGIMGSPKPAIKSISASAL
Mouse ELMALPTFGARNLQKHLARAK ASG---SSKPAIQSISASAL
Xenopus laevis ELMTLPTPGALNLKKHLSGVS PQANCGKEGQPIQSISASTL
Xenopus tropicalis ELMTLPTPGALNLKKHFSGVP TQAN-EKGGQPFQSISASAL
Zebrafish GLMSMPTPGALNIKRHLGQSK SSA---VAGSSVQSVSASDL
Drosophila ---------GGPVSRLAGGVE AS-----RKQRVQDLERLRL
Baker's yeast --------------------- ------------------NI
Fission yeast --------------------- -------------ERERKER
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 875
Protein MCM10 homolog
Literature citations
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Wiemann S.; Weil B.; Wellenreuther R.; Gassenhuber J.; Glassl S.; Ansorge W.; Boecher M.; Bloecker H.; Bauersachs S.; Blum H.; Lauber J.; Duesterhoeft A.; Beyer A.; Koehrer K.; Strack N.; Mewes H.-W.; Ottenwaelder B.; Obermaier B.; Tampe J.; Heubner D.; Wambutt R.; Korn B.; Klein M.; Poustka A.;
Genome Res. 11:422-435(2001)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANTS PRO-195 AND SER-541;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANTS SER-541 AND ARG-669;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.