UniProtKB/Swiss-Prot Q12802: Variant p.Arg574Cys

A-kinase anchor protein 13
Gene: AKAP13
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Variant information Variant position:

574 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Arginine (R) to Cysteine (C) at position 574 (R574C, p.Arg574Cys). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from large size and basic (R) to medium size and polar (C) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

-3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources:

Links to websites of interest for the variant.

Variant rs2061824 [ dbSNP | Ensembl ]

Sequence information Variant position:

574 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

2813 The length of the canonical sequence.
Location on the sequence:

AFSNEETSTEKTAETETSRS R EESADAPVDQNSVVIPAAAK The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AFSNEETSTEKTAETETSRSREESADAPVDQNSVVIP---AAAK

Mouse                         ALSSEEIPTEKPGMETQERGCEGGTTS--DQSSPVLP--AA

Rat                           AWSPEEIPTGKPGMETQERGCEGGITS--DQSSQVLPAAAA

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 2813	A-kinase anchor protein 13
Region	539 – 585	Disordered
Compositional bias	562 – 579	Basic and acidic residues
Alternative sequence	180 – 2813	Missing. In isoform 4.

Literature citations
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann E.; Edemir B.; Pepperle B.; Tamma G.; Henn V.; Klauschenz E.; Hundsrucker C.; Maric K.; Rosenthal W.;
FEBS Lett. 507:264-268(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); SUBCELLULAR LOCATION; VARIANTS CYS-574 AND SER-2457; Submission
Miyamoto M.; Ono Y.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-452; ARG-494; CYS-574; LYS-689; ALA-845; MET-897; ALA-1062; ASN-1086 AND THR-1216;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.