Variant position: 897 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2813 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PPAIPEALNIKGNTDSSLQS VGKATLALDSVLTEEGKLLVV
Mouse PTATLEVL-----SDSLLHN VDKAALVSDFTLPEEGVSVVV
Rat LTATLEVL-----SDSLLQS VDKAALVSDSLLPEEGGSIVV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2813 A-kinase anchor protein 13
180 – 2813 Missing. In isoform 4.
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.
Diviani D.; Soderling J.; Scott J.D.;
J. Biol. Chem. 276:44247-44257(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH PKA HOLOENZYME; PRKAR2A; GNA12; RHOA; RHOB AND RHOC; IDENTIFICATION IN A COMPLEX WITH RHOA AND PRKAR2A; MUTAGENESIS OF ALA-1251; ILE-1260 AND TYR-2153; VARIANTS VAL-624; MET-897 AND SER-2457;
Miyamoto M.; Ono Y.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS THR-452; ARG-494; CYS-574; LYS-689; ALA-845; MET-897; ALA-1062; ASN-1086 AND THR-1216;
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