Variant position: 2457 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2813 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GNLGGTLGPTVSSPIEQDVV- GPVSLPRRAETFGGFDSHQMN
Mouse GSLGGTLGQSISSPVEQEVMA APISLPRRAETFGGFDCHQM
Rat GSLGGTLGQPISSPVEQEVMA GPISLPRRAETFGGFDCHQL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann E.; Edemir B.; Pepperle B.; Tamma G.; Henn V.; Klauschenz E.; Hundsrucker C.; Maric K.; Rosenthal W.;
FEBS Lett. 507:264-268(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); SUBCELLULAR LOCATION; VARIANTS CYS-574 AND SER-2457;
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.
Diviani D.; Soderling J.; Scott J.D.;
J. Biol. Chem. 276:44247-44257(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH PKA HOLOENZYME; PRKAR2A; GNA12; RHOA; RHOB AND RHOC; IDENTIFICATION IN A COMPLEX WITH RHOA AND PRKAR2A; MUTAGENESIS OF ALA-1251; ILE-1260 AND TYR-2153; VARIANTS VAL-624; MET-897 AND SER-2457;
Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.
Rubino D.; Driggers P.; Arbit D.; Kemp L.; Miller B.; Coso O.; Pagliai K.; Gray K.; Gutkind S.; Segars J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1385-2813 (ISOFORM 1); FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH ESR1; THRA AND PPARA; VARIANT SER-2457;
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1486-2813 (ISOFORM 3); VARIANT SER-2457;
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