Variant position: 2141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2458 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IIQQAGQVWFPDSAYKTAQA VKDFNREKLPLMIFANWRGFS
Mouse IIQQAGQVWFPDSAYKTAQV IRDFNKERLPLMIFANWRGFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
Cheng D.; Chu C.-H.; Chen L.; Feder J.N.; Mintier G.A.; Wu Y.; Cook J.W.; Harpel M.R.; Locke G.A.; An Y.; Tamura J.K.;
Protein Expr. Purif. 51:11-21(2007)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; COFACTOR; BIOPHYSICOCHEMICAL PROPERTIES; CATALYTIC ACTIVITY; ACTIVITY REGULATION; VARIANT ILE-2141;
Corrected sequence for human acetyl-CoA carboxylase 2 obtained by alignment to human genomic DNA and PCR cloning from human skeletal muscle and heart cDNA.
Peng X.R.; Lindgren K.; Corneliussen B.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ILE-2141;
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