Variant position: 28 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 448 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SNMERESGKPVAVVAVVTEP WFTQRYREYLQRQKLFDTQHR
Mouse ---MERECEESVVVAVVTEP RFTQRYRDYLEEQKLLDRLHR
Rat ---MERECEKSVVVAVVTEP RFTQRYRDYLEKQKLLDRQYR
Bovine --MEGAGGKPTAVVAVVTEP RFTQRYREYLEKHKLLDRQHR
Zebrafish ---------MDVVPCLKVPQ RHAQMYRKYLESQGVLDRRYG
Baker's yeast -----MSDETMPVEFLVSDK RLLKTIKVKLETNGLF--VTP
Fission yeast ------------MISFLVQK SEAKYWKDVVQNKNKF-----
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 448 tRNA wybutosine-synthesizing protein 2 homolog
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT ARG-28;
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