Variant position: 148 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 390 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QVTIGFGGRMVTEECPLAIL ILIVQNIVGLMINAIMLGCIF
Mouse QVTIGFGGRMVTEECPLAIL ILIVQNIVGLMINAIMLGCIF
Rat QVTIGFGGRMVTEECPLAIL ILIVQNIVGLMINAIMLGCIF
Rabbit QVTIGFGGRMVTEECPLAIL ILIVQNIVGLMINAIMLGCIF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 390 ATP-sensitive inward rectifier potassium channel 11
145 – 166 Helical; Name=M2
160 – 160 Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Inagaki N.; Gonoi T.; Clement J.P. IV; Namba N.; Inazawa J.; Gonzalez G.; Aguilar-Bryan L.; Seino S.; Bryan J.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT SER-148;
Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy.
Ohkubo K.; Nagashima M.; Naito Y.; Taguchi T.; Suita S.; Okamoto N.; Fujinaga H.; Tsumura K.; Kikuchi K.; Ono J.;
Clin. Endocrinol. (Oxf.) 62:458-465(2005)
Cited for: VARIANT HHF2 HIS-34; VARIANTS LYS-23; SER-148 AND VAL-337;
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