Variant position: 218 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 389 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KAYITWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTAAA
Rhesus macaque KAYITWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTAAA
Mouse KAYVTWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTAAA
Rat KAYVTWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTAAA
Pig KAYITWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTAAE
Bovine KAYITWITLAVYIVPVIVLA TCYGLISFKIWQNLRLKTAAA
Sheep KAYITWITLAVYIVPVIVLA ACYGLISFKIWQNLRLKTEAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 389 Oxytocin receptor
203 – 225 Helical; Name=5
Structure and expression of a human oxytocin receptor.
Kimura T.; Tanizawa O.; Mori K.; Brownstein M.J.; Okayama H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT THR-218;
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
Kopatz S.A.; Aronstam R.S.; Sharma S.V.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT THR-218;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.