Variant position: 221 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 248 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KLHKPGKDASKRGRQTPVLY AMLDHSRSTKAVSEKKAKG-LG
Mouse RFHKSSKDSSKRGRQTPVLY AMLDHSRSTKAASEKKSKG-L
Rat KFHKSSKDSSKRGRQTPVLY AMLDHSRSTKAASEKKSKG-L
Bovine KLHKTAKDASKRGRQTPVLY AMLDHSRSTKAASEKKTKG-L
Horse KLHKPGKDTSKRGRQTPVLY AMLDHSRSTKAASEKKAKG-L
Chicken KLQRSAKDASKRSRQPPVLY AMLDHSRSAKAAAEKKSKGAP
Xenopus laevis KLHKAKDSSKRSSRQTPILY AMLDQTRGK--SSEKKAKGGI
Xenopus tropicalis KLHKAKDSSKRSSRQTPILY AMLDQTRGK--ASEKKGKGGI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
30 – 248 Myelin protein P0
180 – 248 Cytoplasmic
210 – 210 Phosphoserine; by PKC
226 – 226 Phosphoserine
228 – 228 Phosphoserine
233 – 233 Phosphoserine; by PKC
The range of chronic demyelinating neuropathy of infancy: a clinico-pathological and genetic study of 15 unrelated cases.
Plante-Bordeneuve V.; Parman Y.; Guiochon-Mantel A.; Alj Y.; Deymeer F.; Serdaroglu P.; Eraksoy M.; Said G.;
J. Neurol. 248:795-803(2001)
Cited for: VARIANTS DSS VAL-42 DEL AND THR-221;
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