Variant position: 80 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 786 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LWTSDILSLSKLRILIISHN RIQYLDISVFKFNQELEYLDL
Mouse LQTSDILSLSKLRVLIMSYN RLQYLNISVFKFNTELEYLDL
Drosophila LNRTEVVSL--LSSIIDNRD NLESI-------NEAKDFLT-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 786 Toll-like receptor 1
25 – 580 Extracellular
78 – 101 LRR 2
The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.
Georgel P.; Macquin C.; Bahram S.;
PLoS ONE 4:E7803-E7803(2009)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS THR-80 AND ILE-602;
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
Nomura N.; Miyajima N.; Sazuka T.; Tanaka A.; Kawarabayasi Y.; Sato S.; Nagase T.; Seki N.; Ishikawa K.; Tabata S.;
DNA Res. 1:27-35(1994)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT THR-80;
Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Ben-Ali M.; Corre B.; Manry J.; Barreiro L.B.; Quach H.; Boniotto M.; Pellegrini S.; Quintana-Murci L.;
Hum. Mutat. 32:643-652(2011)
Cited for: VARIANTS PRO-44; THR-75; THR-80; TYR-118; SER-248; LEU-305; LEU-315; ASN-352; VAL-460; ALA-542; CYS-554; GLY-587; ILE-602; ALA-651; ALA-674; PRO-720 AND LEU-733; CHARACTERIZATION OF VARIANTS LEU-315; CYS-554; ILE-602; ALA-651 AND PRO-720;
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