Variant position: 582 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 585 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KNQLEKIQKETALLQELEDL ELGI--
Mouse KNQLEKIQKETALLQELEDL ELGV
Chicken KNQLEKIQKESALLQELEDL ELGL
Xenopus laevis KNQIEKIQKEDILLKELEDL EIGV
Zebrafish KNQLEKMQKEAQLLKELEDL ELGL
Caenorhabditis elegans PNQMEKIQRENEYLSELSKL TI--
Drosophila LNQLNKIKMEAQYLDELKAL KQSA
Slime mold PTAIEKINNEQKFLEELRKL QSEL
Baker's yeast DTQVLKIQTEEKVLKDLEKL GWKD
Fission yeast ATQVKKIESEGKVLAELKAL GWTP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 585 Eukaryotic translation initiation factor 2A
2 – 585 Eukaryotic translation initiation factor 2A, N-terminally processed
531 – 582
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LYS-582;
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