Sequence information
Variant position: 312 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 451 The length of the canonical sequence.
Location on the sequence:
HILEDSCAELGESKEHMESR
M VTETEETQEKKAESKEPIEE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HILEDSCAELGES--KEHMESRM VTETEETQEKKAESKEPIEE
Mouse GILENTGTEPGETSDKECNERK- -TVTDPEETPARKETESH
Rat GILENTGTEPGETSTREHNERKT VTVTETEETPARKETESP
Xenopus laevis LHVPQLQSSSKGT--EHIQEPQT CPAESEQNTETPNISDGS
Xenopus tropicalis ----QWQSSSKGT--ELVQESQS IPVESEQNMESQNSSDES
Zebrafish SSSSSPAPKPTEVNQQEMETEME CTAQISSSSSSPAEHSEE
Fission yeast ----SWS--------RRMQASES SNEAEGEDSESQ------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
78 – 451
Replication stress response regulator SDE2
Region
222 – 362
Disordered
Compositional bias
293 – 362
Basic and acidic residues
Modified residue
319 – 319
Phosphothreonine
Modified residue
326 – 326
Phosphoserine
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.