Variant position: 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 641 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRKFGDPVVQSDMKHWPFQV INDGDKPKVQVSYKGETKAFY
Mouse GRKFGDAVVQSDMKHWPFQV VNDGDKPKVQVNYKGESRSFF
Rat GRKFGDPVVQSDMKHWPFQV VNDGDKPKVQVNYKGENRSFY
Pig GRKFGDPVVQADMKHWPFRV INDGDKPKVQVSYKGETKAFY
Bovine GRKFGDPVVQSDMKHWPFRV INDGDKPKVQVSYKGETKAFY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 641 Heat shock 70 kDa protein 1B
2 – 386 Nucleotide-binding domain (NBD)
77 – 77 N6-acetyllysine
108 – 108 N6-acetyllysine
77 – 77 K -> Q. No loss of acetylation and ATPase activity. Exhibits normal protein refolding activity during the early phase but exhibits defects in ubiquitin-mediated protein degradation during the later phase.
77 – 77 K -> R. Significant loss of acetylation and ATPase activity. Decreased binding to HOPX and HSP90 and increased binding to STUB1 and NAA10. Impaired capacity for protein refolding during the early phase after stress but shows normal protein degradation activity in the late phase.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-95; VAL-467 AND SER-499;
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