Sequence information
Variant position: 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 641 The length of the canonical sequence.
Location on the sequence:
GRKFGDPVVQSDMKHWPFQV
I NDGDKPKVQVSYKGETKAFY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRKFGDPVVQSDMKHWPFQVI NDGDKPKVQVSYKGETKAFY
Mouse GRKFGDAVVQSDMKHWPFQVV NDGDKPKVQVNYKGESRSFF
Rat GRKFGDPVVQSDMKHWPFQVV NDGDKPKVQVNYKGENRSFY
Pig GRKFGDPVVQADMKHWPFRVI NDGDKPKVQVSYKGETKAFY
Bovine GRKFGDPVVQSDMKHWPFRVI NDGDKPKVQVSYKGETKAFY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 641
Heat shock 70 kDa protein 1B
Region
2 – 386
Nucleotide-binding domain (NBD)
Modified residue
77 – 77
N6-acetyllysine
Modified residue
108 – 108
N6-acetyllysine
Mutagenesis
77 – 77
K -> Q. No loss of acetylation and ATPase activity. Exhibits normal protein refolding activity during the early phase but exhibits defects in ubiquitin-mediated protein degradation during the later phase.
Mutagenesis
77 – 77
K -> R. Significant loss of acetylation and ATPase activity. Decreased binding to HOPX and HSP90 and increased binding to STUB1 and NAA10. Impaired capacity for protein refolding during the early phase after stress but shows normal protein degradation activity in the late phase.
Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-95; VAL-467 AND SER-499;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.