Variant position: 101 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 660 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FGLPQTGDLDQNTIETMRKP RCGNPDVANYNFFPRKPKWDK
Mouse FGLPQTGDLDQNTIETMRKP RCGNPDVANYNFFPRKPKWDK
Rat FGLPQTGDLDQNTIETMRKP RCGNPDVANYNFFPRKPKWDK
Bovine FGLPQTGELDQSTIETMRKP RCGNPDVANYNFFPRKPKWDK
Rabbit FGLPQTGELDQSTIETMRKP RCGNPDVANYNFFPRKPKWDK
Chicken FGLPETGDLDQNTIETMKKP RCGNPDVANYNFFPRKPKWEK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
30 – 109 Activation peptide
100 – 107 Cysteine switch
102 – 102 Zinc 1; in inhibited form
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.
Martignetti J.A.; Aqeel A.A.; Sewairi W.A.; Boumah C.E.; Kambouris M.; Mayouf S.A.; Sheth K.V.; Eid W.A.; Dowling O.; Harris J.; Glucksman M.J.; Bahabri S.; Meyer B.F.; Desnick R.J.;
Nat. Genet. 28:261-265(2001)
Cited for: VARIANT MONA HIS-101; VARIANT TYR-210; CATALYTIC ACTIVITY;
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