Variant position: 627 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 767 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GIYTLYPFINS-RIITVSMED VKILLT----QENPFFRKLSSETYS
Mouse GIYTLYPFINS-RIITVSMED VKTLLT----QENPFFRKLS
Chicken GIYTLYPFIHA-RIVNVCIED VKILLT----QENPFLSKFS
Xenopus laevis GIYSLYPFINA-RILTVSVED IKVLLT----QENPFLSKFS
Xenopus tropicalis GIYTLYPFINA-RIVTVSIED IKVLLT----QENPFLSKFS
Drosophila GLQTSNAFMGASRRIQVERED LVMMLNCTDPTQPPSTHELK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 767 RNA cytosine C(5)-methyltransferase NSUN2
640 – 640 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
No reference for the current variant in UniProtKB/Swiss-Prot.
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