Variant position: 163 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 243 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FTCQVPGVYYFAVHATVYRA SLQFDLVKNGESIASFFQFFG
Mouse FTCQVPGVYYFAVHATVYRA SLQFDLVKNGQSIASFFQYFG
Rat FTCQVPGVYYFAVHATVYRA SLQFDLVKNGQSIASFFQFFG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
16 – 243 Complement C1q tumor necrosis factor-related protein 5
99 – 238 C1q
149 – 170
Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration.
Tu X.; Palczewski K.;
J. Struct. Biol. 180:439-446(2012)
Cited for: X-RAY CRYSTALLOGRAPHY (1.34 ANGSTROMS) OF 103-243; SUBUNIT; VARIANT LORD ARG-163;
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration.
Hayward C.; Shu X.; Cideciyan A.V.; Lennon A.; Barran P.; Zareparsi S.; Sawyer L.; Hendry G.; Dhillon B.; Milam A.H.; Luthert P.J.; Swaroop A.; Hastie N.D.; Jacobson S.G.; Wright A.F.;
Hum. Mol. Genet. 12:2657-2667(2003)
Cited for: VARIANT LORD ARG-163;
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