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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9BY76: Variant p.Arg336Cys

Angiopoietin-related protein 4
Gene: ANGPTL4
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Variant information Variant position: help 336 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Arginine (R) to Cysteine (C) at position 336 (R336C, p.Arg336Cys). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (C) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help Genetic variations in ANGPTL4 are associated with low plasma triglyceride levels and define the plasma triglyceride level quantitative trait locus (TGQTL) [MIM:615881]. Additional information on the polymorphism described.
Variant description: help No effect on protein folding. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 336 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 406 The length of the canonical sequence.
Location on the sequence: help TVPPSGLSVPFSTWDQDHDL R RDKNCAKSLSGGWWFGTCSH The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         TVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSH

Mouse                         NVSPNGLSLPFSTWDQDHDLRGDLNCAKSLSGGWWFGTCSH

Rat                           NVSPNGLSLPFSTWDQDHDLRGDLNCAKSLSGGWWFGTCSH

Pig                           IDTPSGLSLPFSTWDQDHDLRGDKNCAKILSGGWWFGTCSH

Bovine                        TFSPSGLSLPFSTWDQDHDLRGDKNCARSLSGGWWFGTCSH

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 26 – 406 Angiopoietin-related protein 4
Chain 164 – 406 ANGPTL4 C-terminal chain
Domain 179 – 401 Fibrinogen C-terminal



Literature citations
Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.
Biterova E.; Esmaeeli M.; Alanen H.I.; Saaranen M.; Ruddock L.W.;
Sci. Rep. 8:6752-6752(2018)
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 184-406; DISULFIDE BONDS; CHARACTERIZATION OF VARIANTS CYS-336; CYS-349 AND SER-361; MUTAGENESIS OF GLY-223; Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.
Romeo S.; Pennacchio L.A.; Fu Y.; Boerwinkle E.; Tybjaerg-Hansen A.; Hobbs H.H.; Cohen J.C.;
Nat. Genet. 39:513-516(2007)
Cited for: ASSOCIATION WITH TGQTL; VARIANTS LEU-5; LYS-40; ILE-41; ARG-67; LEU-72; ARG-77; LYS-167; SER-174; GLN-190; LYS-196; CYS-230; ARG-233; VAL-237; THR-251; MET-266; GLN-278; MET-291; MET-293; VAL-296; SER-307; MET-308; CYS-336; GLU-338; CYS-349; SER-361; ARG-361; GLN-371 AND TRP-384;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.