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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q07912: Variant p.Lys71Arg

Activated CDC42 kinase 1
Gene: TNK2
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Variant information Variant position: help 71
Type of variant: help LB/B
Residue change: help From Lysine (K) to Arginine (R) at position 71 (K71R, p.Lys71Arg).
Physico-chemical properties: help Similar physico-chemical property. Both residues are large size and basic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 71
Protein sequence length: help 1038
Location on the sequence: help MGRPGQRRLWEAVKRRKALC K RKSWMSKVFSGKRLEAEFPP
Residue conservation: help 
Human                         MGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPP

Mouse                         MGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLEAEFPS

Rat                           MGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRQEAEFPS

Bovine                        MGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLEAEFPP

Baker's yeast                 QGQP-QPNLYD----------------------KHINMFPP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1038 Activated CDC42 kinase 1
Region 1 – 110 SAM-like domain



Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS LEU-34; ARG-71; GLN-99; TRP-99; MET-152; LYS-346; ILE-409; SER-507; LEU-725; GLN-748 AND HIS-1038;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.