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UniProtKB/Swiss-Prot P29323: Variant p.Met883Val

Ephrin type-B receptor 2
Gene: EPHB2
Variant information

Variant position:  883
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LP/P [Disclaimer]
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Methionine (M) to Valine (V) at position 883 (M883V, p.Met883Val).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In prostate cancer.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  883
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  1055
The length of the canonical sequence.

Location on the sequence:   WQKDRNHRPKFGQIVNTLDK  M IRNPNSLKAMAPLSSGINLP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         WQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLP

Mouse                         WQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLP

Chicken                       WQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGVNLP

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 19 – 1055 Ephrin type-B receptor 2
Chain 536 – 986 EphB2/CTF1
Chain 562 – 986 EphB2/CTF2
Topological domain 565 – 1055 Cytoplasmic
Domain 621 – 884 Protein kinase
Helix 873 – 885


Literature citations

A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.
Kittles R.A.; Baffoe-Bonnie A.B.; Moses T.Y.; Robbins C.M.; Ahaghotu C.; Huusko P.; Pettaway C.; Vijayakumar S.; Bennett J.; Hoke G.; Mason T.; Weinrich S.; Trent J.M.; Collins F.S.; Mousses S.; Bailey-Wilson J.; Furbert-Harris P.; Dunston G.; Powell I.J.; Carpten J.D.;
J. Med. Genet. 43:507-511(2006)
Cited for: VARIANTS PROSTATE CANCER SER-279; ALA-650 AND VAL-883;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.