Variant position: 302 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 416 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IPELKQDISIPDYCSLGDGE EEEITINAWFGPQGTISPLHQ
Mouse IPELKRDISIPDYCCLGNGE EEEITINAWFGPQGTISPLHQ
Rat IPELKQDISIPDYCCLGNGE EEEITINAWFGPQGTISPLHQ
Bovine IPELKQDISIPDYCCLGDGE EEEITINAWFGPQGTVSPLHQ
Xenopus tropicalis IPELKEDICIPDYCCLGEAS EDEITINAWFGPAGTVSPLHQ
Zebrafish VPELKEDIRIPDYCCLGEGD EDDITINAWFGPGGTVSPLHQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 416 Bifunctional peptidase and arginyl-hydroxylase JMJD5
271 – 416 JmjC
321 – 321 Iron; catalytic
318 – 318 2-oxoglutarate
318 – 318 N(omega)-methyl-L-arginine and symmetrical N(omega),N'(omega)-dimethyl-L-arginine binding; via carbonyl oxygen
321 – 321 2-oxoglutarate
167 – 362 Missing. In isoform 2.
310 – 310 W -> A. Loss of L-arginyl 3-hydroxylase activity toward RPS6.
321 – 321 H -> A. Loss of H3K36me2 demethylase activity.
321 – 321 H -> A. Loss of L-arginyl 3-hydroxylase activity toward RPS6. Loss of peptidase activity toward methylated histones; when associated with A-323 and A-400. No effect on its regulatory function on the circadian clock or CRY1 stability.
302 – 304
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.