Variant position: 159 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 806 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Mouse FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Rat FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Pig FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Bovine FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Xenopus laevis FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Xenopus tropicalis FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Zebrafish FLEAYRPIRKGDIFLVRGGM RAVEFKVVETDPSPYCIVAPD
Drosophila FLEAYRPIHMGDNFIVRAAM RPIEFKVVLTDPEPYCIVAPE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 806 Transitional endoplasmic reticulum ATPase
157 – 159
Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene.
Haubenberger D.; Bittner R.E.; Rauch-Shorny S.; Zimprich F.; Mannhalter C.; Wagner L.; Mineva I.; Vass K.; Auff E.; Zimprich A.;
Cited for: VARIANT IBMPFD1 HIS-159;
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