Variant position: 168 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 493 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CDSGRVRTDAPDCYLSFHKL LLHLQGEREPGWIKQLFTNFI
Chicken CQEEQVAADASDCYLSFHKL MLHLQGDKEPGWLKQLFTDFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
18 – 493 Cholesteryl ester transfer protein
160 – 201
155 – 155 T -> Y. Reduces triglyceride transfer and cholesteryl ester transfer 5-fold.
152 – 171
Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay.
Nagano M.; Yamashita S.; Hirano K.; Ito M.; Maruyama T.; Ishihara M.; Sagehashi Y.; Oka T.; Kujiraoka T.; Hattori H.; Nakajima N.; Egashira T.; Kondo M.; Sakai N.; Matsuzawa Y.;
J. Lipid Res. 43:1011-1018(2002)
Cited for: VARIANTS HALP1 PRO-168 AND CYS-299; CHARACTERIZATION OF VARIANTS HALP1 PRO-168 AND CYS-299;
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