Sequence information
Variant position: 287 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 631 The length of the canonical sequence.
Location on the sequence:
CVEVLPDRDGKRCMFCVKTA
N RTYEMSASDTRQRQEWTAAI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CVEVLPDRDGKRCMFCVKTAN RTYEMSASDTRQRQEWTAAI
Mouse CVEVLPDREGKRCMFCVKTAS RTYEMSASDTRQRQEWTAAI
Xenopus laevis GVEILPDRDGRRCMFCVKTTS KTHEMCASDTKHRQEWVTAI
Zebrafish CVEVLPDRDGKRCMFCLKTLT KTYELSASDTKQRQEWTTAI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 631
Differentially expressed in FDCP 6 homolog
Domain
216 – 312
PH
Literature citations
Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.
Gupta S.; Lee A.E.; Hu C.; Fanzo J.C.; Goldberg I.; Cattoretti G.; Pernis A.B.;
Hum. Immunol. 64:389-401(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH IRF4; VARIANT THR-287;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.