Variant position: 287 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 631 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CVEVLPDRDGKRCMFCVKTA NRTYEMSASDTRQRQEWTAAI
Mouse CVEVLPDREGKRCMFCVKTA SRTYEMSASDTRQRQEWTAAI
Xenopus laevis GVEILPDRDGRRCMFCVKTT SKTHEMCASDTKHRQEWVTAI
Zebrafish CVEVLPDRDGKRCMFCLKTL TKTYELSASDTKQRQEWTTAI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 631 Differentially expressed in FDCP 6 homolog
216 – 312 PH
Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.
Gupta S.; Lee A.E.; Hu C.; Fanzo J.C.; Goldberg I.; Cattoretti G.; Pernis A.B.;
Hum. Immunol. 64:389-401(2003)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; INTERACTION WITH IRF4; VARIANT THR-287;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.