Variant position: 195 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1687 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SHDAESEREDPAPAKKMVED GQSGDLEKKADEVFHCPVCFK
Mouse SHDAES--EDPGPAKKMVED GQSGDLDKMSDEIFHCPVCFK
Chicken SQDAEMDREERTPAKKVVED GQYGEGDRKEDDAYHCPVCFK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1687 Ras-responsive element-binding protein 1
145 – 197 Disordered
172 – 197 Basic and acidic residues
175 – 175 Phosphoserine
180 – 180 Phosphoserine
203 – 203 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
1 – 1200 Missing. In isoform 4.
Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.
Date S.; Nibu Y.; Yanai K.; Hirata J.; Yagami K.; Fukamizu A.;
Int. J. Mol. Med. 13:637-642(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3); VARIANTS ARG-195; VAL-783 AND PRO-1467; SUBCELLULAR LOCATION; FUNCTION;
RREB1 transcription factor splice variants in urologic cancer.
Nitz M.D.; Harding M.A.; Smith S.C.; Thomas S.; Theodorescu D.;
Am. J. Pathol. 179:477-486(2011)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6); ALTERNATIVE SPLICING; VARIANTS ARG-195 AND VAL-783;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4); NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-324 (ISOFORM 1); VARIANTS ARG-195 AND PRO-1467;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.