Variant position: 556 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 593 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AQPPAPTPTSAPNKGGGGGG GSSSNAGGRGGNTGT--SGGQAG
Mouse AQPPPPTAPSAPGKGGVSSI GTNTTTGSRTGASGSTVSGGQ
Xenopus laevis AQPPT------------SAS GTSKGSSNRTGSIGGGSSNSQ
Xenopus tropicalis AQPPT------------SAS GTSKGSSNRTGSIGGGSSTSQ
Zebrafish ARKPA--------IGFMPSS QRVHHQHSSQGKSNSPGLSSH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 593 AT-rich interactive domain-containing protein 3A
537 – 557 Important for cytoplasmic localization
550 – 579 Gly-rich
A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer.
Suzuki M.; Okuyama S.; Okamoto S.; Shirasuna K.; Nakajima T.; Hachiya T.; Nojima H.; Sekiya S.; Oda K.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INTERACTION WITH E2F1; VARIANT SER-556;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS HIS-36; GLU-320 AND SER-556;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.